Programme
Mechanisms and Consequences of
Chromosomal Translocations in Cancer
Paris, May 20-21, 2019
 
Monday, May 20, 2019
Welcoming participants
08:30 am-08:45 am
Introductory remarks
08:45 am-09:00 am
Session 1: Origins and mechanisms of chromosomal translocation formation
09:00 am-12:15 pm
0
09:00 am

Topoisomerase II-induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

A. Nussenzweig
Laboratory of Genome Integrity, National Cancer Institute, Nih, Bethesda, Md, United States 
0
09:35 am

Short talk to be selected


0
09:50 am

Short talk to be selected


0
10:05 am

Informal discussion / Coffee break


0
10:35 am

Mammalian RAD51 generates genetic instability through non-homologous events

B. Lopez
CNRS UMR 8200, Institut de Cancérologie Gustave-Roussy, Villejuif, France 
0
11:10 am

Short talk to be selected


0
11:25 am

Short talk to be selected


0
11:40 am

Maintenance of genome integrity through protection of broken DNA and telomeres from aberrant DNA end processing

J. Jacobs
Division of Oncogenomics, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands 
Lunch
12:15 pm-01:45 pm
Session 2: Toward a faithful modelling of chromosomal translocations
01:45 pm-04:25 pm
0
01:45 pm

Modeling translocation using genome editing tools

M. Jasin
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, Ny, 10065, United States 
0
02:20 pm

Short talk to be selected


0
02:35 pm

Short talk to be selected


0
02:50 pm

Informal discussion / Coffee break


0
03:20 pm

CRISPR/Cas9-mediated t(11;19) induce leukaemia in vivo

D. Heckl
Pediatric Hematology & Oncology, Hannover Medical School, Hannover, Germany 
0
03:55 pm

Short talk to be selected


0
04:10 pm

Short talk to be selected


Poster session – wine and cheese
04:30 pm-06:30 pm
Tuesday, May 21, 2019
Session 3 (part 1): Diseases, functional consequences and treatment perspectives
09:00 am-12:00 pm
0
09:00 am

Identification of actionable gene fusions in a precision oncology program

S. Fröhling
Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany 
0
09:35 am

Short talk to be selected


0
09:50 am

Short talk to be selected


0
10:05 am

Informal discussion / Coffee break


0
10:35 am

Critical oncogenic determinants in fatal TCF3-HLF rearranged leukemia

J.P. Bourquin
Division of Pediatric Oncology, and Children Research Center, University Children's Hospital, Ch 8032 Zurich, Switzerland 
0
11:10 am

Short talk to be selected


0
11:25 am

Establishment of specific gene regulatory networks by different leukemic fusion proteins

C. Bonifer
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom 
Lunch
12:10 pm-01:30 pm
Session 3 (part 2): Diseases, functional consequences and treatment perspectives
01:45 pm-03:25 pm
0
01:45 pm

Molecular basis of APL eradication by retinoic acid and arsenic

H. de Thé
INSERM U944, CNRS UMR 7212, Collège de France, AP-HP, Hôpital St Louis, Paris, France 
0
02:20 pm

Short talk to be selected


0
02:35 pm

Short talk to be selected


0
02:50 pm

Ewing Sarcoma Translocation: from molecular pathways to oncogenesis

O. Delattre
INSERM U830, Institut Curie, Paris 75005, France 
Concluding remarks
03:25 pm-03:40 pm
0
03:25 pm

L. Deriano, E. Brunet and T. Mercher


 

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