Mechanisms and Consequences of
Chromosomal Translocations in Cancer
Paris, May 20-21, 2019
Auditorium François Jacob
Monday, May 20, 2019
Welcoming participants (François Jacob Auditorium)
08:00 am-08:45 am
Introductory remarks
08:45 am-09:00 am
Session 1: Origins and mechanisms of chromosomal translocation formation
09:00 am-12:15 pm
09:00 am

Topoisomerase II-induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

André Nussenzweig
National Cancer Institute, Nih, Bethesda, Md, United States
09:35 am

Does a balance exist between class switch recombination and locus suicide recombination in B-cells?

Sophie Péron
CRIBL, Limoges, France
09:50 am

Unrepaired G1 DNA double-strand breaks undergo Pol q-mediated alternative end joining and translocations in S-G2-M

Wei Yu
Institut Pasteur, Paris, France
10:05 am

Informal discussion / Coffee break

10:35 am

Mammalian RAD51 generates genetic instability through non-homologous events

Bernard Lopez
CNRS UMR 8200, Institut de Cancérologie Gustave-Roussy, Villejuif, France
11:10 am

Cyclin A2/E1 activation defines a hepatocellular cacrinoma subclass with a rearrangement signature of replication stress

Quentin Bayard
INSERM, Paris, France
11:25 am

Dissecting the role of oncogenic H3.3 mutations in genome instability and oncogenesis

Beatrice Rondinelli
UMR 7216 CNRS- Univ Diderot, Paris, France
11:40 am

Maintenance of genome integrity through protection of broken DNA and telomeres from aberrant DNA end processing

Jacqueline Jacobs
The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
12:15 pm-01:45 pm
Session 2: Toward a faithful modelling of chromosomal translocations
01:45 pm-04:25 pm
01:45 pm

Modeling translocation using genome editing tools

Maria Jasin
Memorial Sloan Kettering Cancer Center, New York, United States
02:20 pm

Engineering targeted and multiple translocations at base-pair resolution with CRISPR/Cas9

Gilles Fischer
Sorbonne Université, Paris, France
02:35 pm

Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations

Henrike Gothe
IMB Mainz, Mainz, Germany
02:50 pm

Informal discussion / Coffee break

03:20 pm

CRISPR/Cas9-mediated t(11;19) induce leukaemia in vivo

Dirk Heckl
Hannover Medical School, Hannover, Germany
03:55 pm

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

Laura Jamrog
Centre de Recherche en Cancérologie de Toulouse - U1037, Toulouse, France
04:10 pm

Restoration of progenitor-like features in mature T lymphocytes after transformation by the NPM-ALK chimeric tyrosine kinase

Nina Caillet
Inserm, Toulouse, France
Poster session – wine and cheese
04:30 pm-06:30 pm
Tuesday, May 21, 2019
Session 3 (part 1): Diseases, functional consequences and treatment perspectives
09:00 am-11:45 am
09:00 am

Molecular basis of APL eradication by retinoic acid and arsenic

Hugues de Thé
Hôpital St Louis, Paris, France
09:35 am

 Ontogenic changes in hematopoietic hierarchy determines pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia

Cécile Lopez
INSERM, Villejuif, France
09:50 am

Informal discussion / Coffee break

10:20 am

Identification of actionable gene fusions in a precision oncology program

Stefan Fröhling
National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany
10:55 am

Targeting genome accessibility as a potential new therapeutic strategy for pediatric sarcoma

Joana Graca Marques
Kinderspital Zurich, Zurich, Switzerland
11:10 am

Establishment of specific gene regulatory networks by different leukemic fusion proteins

Constanze Bonifer
University of Birmingham, Birmingham, United Kingdom
11:45 am-01:30 pm
Session 3 (part 2): Diseases, functional consequences and treatment perspectives
01:30 pm-02:55 pm
01:30 pm

Critical oncogenic determinants in fatal TCF3-HLF rearranged leukemia

Yun Huang
Kinderspital, Zurich, Switzerland
02:05 pm

Deletion 6q impairs ribosomal and mitochondrial functions to drive leukemia progression in T-cell Acute Lymphoblastic Leukemia

Stéphanie Gachet
Institut de Recherche Saint Louis, Paris, France
02:20 pm

Ewing Sarcoma Translocation: from molecular pathways to oncogenesis

Olivier Delattre
Institut Curie, Paris, France
Concluding remarks
02:55 pm-03:15 pm
02:55 pm

L. Deriano, E. Brunet and T. Mercher


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